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CHRONIC MYELOID LEUKEMIA- DIAGNOSIS

A very important topic of Hematology by Dr Shagun Mehta, MD Path and Creator of Pathology Bytes.

PERIPHERAL SMEAR -

• Myelocyte and Metamyelocyte Bulge

• increase in eosinophils

•increase in basophils

BONE MARROW-

• Hypercellular

• Sea- Blue histiocytes

• Pseudo Gaucher cells

LAP / NAP SCORE-

• Normal = 40-100

• Decreased in CML

CYTOGENETICS-

• IOC - FISH { t(9;22) }

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