DIAGNOSIS OF CML-
PERIPHERAL SMEAR -
• Myelocyte and Metamyelocyte Bulge
• increase in eosinophils
•increase in basophils
BONE MARROW-• Hypercellular
• Sea- Blue histiocytes
• Pseudo Gaucher cells
LAP / NAP SCORE-• Normal = 40-100
• Decreased in CML
CYTOGENETICS-
• IOC - FISH { t(9;22) }

