CHRONIC MYELOID LEUKEMIA- PATHOGENESIS

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CHRONIC MYELOID LEUKEMIA- PATHOGENESIS

A very important topic of Hematology by Dr Shagun Mehta, MD Path and Creator of Pathology Bytes.

PATHOGENESIS -

• There is translocation (9;22) which results in the formation of BCR-ABL fusion protein which causes increase in tyrosine kinase activity leading to increase in proliferation of cells

• There is translocation of ABL gene from chr 9 to BCR gene on chr 22

• Now , this chr 22 with both BCR and ABL fusion gene is called as PHILADELPHIA CHROMOSOME.

BCR-ABL fusion protein in CML is a 210 kD protein

BCR- ABL fusion protein in ALL is a 190 kD protein

BCR- ABL fusion protein in CNL (chronic neutrophilic leukemia ) is a 230 kD protein .

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