Clinical Pathology - Quiz Section Solution with Explanation- Quiz 1

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Clinical Pathology - Quiz Section Solution with Explanation- Quiz 1

This is a unique clinical case series based quiz run by Dr Shagun Mehta ( MD , Path )- Creator of Pathology Bytes

Approach to this case will be-

- The given histological picture shows NESTS of POLYGONAL TUMOR CELLS embedded in collagenous framework and

- Associated with AMYLOID in stroma which

- represents the deposition of PROCALCITONIN and

- This is a characteristic feature of MEDULLARY CARCINOMA OF THYROID and

- Its origin is from PARAFOLLICULAR CELLS (C-CELLS) which secrete calcium lowering hormone- CALCITONIN and

- Associated with sporadic and FAMILIAL (AUTOSOMAL DOMINANT INHERITANCE) cases and

- Such patients often have symptoms related to endocrine secretion and

- Watery diarrhoea is seen in one third of patients caused by vasoactive intestinal peptide

** THE ANSWER IS 4) CALCITONIN**

Polygonal tumor cells with amyloid depostion in stroma in case of MEDULLARY THYROID CARCINOMA
Polygonal tumor cells with amyloid depostion in stroma in case of MEDULLARY THYROID CARCINOMA

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