Clinical Pathology - Quiz Section Solution with Explanation- Quiz 2

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Clinical Pathology - Quiz Section Solution with Explanation- Quiz 2

This is a unique clinical case series based quiz run by Dr Shagun Mehta ( MD , Path )- Creator of Pathology Bytes

The given histological picture shows fine , LACE LIKE PATTERN OF NEOPLASTIC BONE produced by tumor cells and

๐Ÿ“Œ MALIGNANT CELLS PRODUCING OSTEOID (dense, pink, amorphous intercellular material) is the HISTOLOGICAL HALLMARK of OSTEOSARCOMA and

๐Ÿ“Œ Osteosarcoma is MOST COMMONLY seen in MALES and

๐Ÿ“Œ It has BIMODAL INCIDENCE (MOSTLY OCCURING BEFORE THE AGE OF 20 YEARS) and

๐Ÿ“Œ MOST COMMON SITE is DISTAL FEMUR OR PROXIMAL TIBIA and

๐Ÿ“Œ LOWER END OF FEMUR is MORE COMMONLY affected. Therefore,

๐Ÿ“Œ The final diagnosis is OSTEOSARCOMA and

๐Ÿ“Œ They are associated with-
โœ… Germline mutations
in RB gene
โœ… p53 mutation
โœ… INACTIVATION of
INK4a gene
โœ… MDM2 and CDK4
OVEREXPRESSION

๐ŸŽ‰ The answer is 3) MDM2 and CDK4 overexpression

๐ŸŽ Mutations in IDH1 and IDH2 genes are generally associated with ENCHONDROMAS

๐ŸŽ Mutations in EXT1 or EXT2 genes are generally associated with OSTEOCHONDROMA

Malignant cells producing LACE LIKE osteoid in a case of Osteosarcoma
Malignant cells producing LACE LIKE osteoid in a case of Osteosarcoma

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