The given histological picture shows fine , LACE LIKE PATTERN OF NEOPLASTIC BONE produced by tumor cells and
📌 MALIGNANT CELLS PRODUCING OSTEOID (dense, pink, amorphous intercellular material) is the HISTOLOGICAL HALLMARK of OSTEOSARCOMA and
📌 Osteosarcoma is MOST COMMONLY seen in MALES and
📌 It has BIMODAL INCIDENCE (MOSTLY OCCURING BEFORE THE AGE OF 20 YEARS) and
📌 MOST COMMON SITE is DISTAL FEMUR OR PROXIMAL TIBIA and
📌 LOWER END OF FEMUR is MORE COMMONLY affected. Therefore,
📌 The final diagnosis is OSTEOSARCOMA and
📌 They are associated with-
✅ Germline mutations
in RB gene
✅ p53 mutation
✅ INACTIVATION of
INK4a gene
✅ MDM2 and CDK4
OVEREXPRESSION
🎉 The answer is 3) MDM2 and CDK4 overexpression
🎁 Mutations in IDH1 and IDH2 genes are generally associated with ENCHONDROMAS
🎁 Mutations in EXT1 or EXT2 genes are generally associated with OSTEOCHONDROMA
