The given histological picture shows fine , LACE LIKE PATTERN OF NEOPLASTIC BONE produced by tumor cells and
๐ MALIGNANT CELLS PRODUCING OSTEOID (dense, pink, amorphous intercellular material) is the HISTOLOGICAL HALLMARK of OSTEOSARCOMA and
๐ Osteosarcoma is MOST COMMONLY seen in MALES and
๐ It has BIMODAL INCIDENCE (MOSTLY OCCURING BEFORE THE AGE OF 20 YEARS) and
๐ MOST COMMON SITE is DISTAL FEMUR OR PROXIMAL TIBIA and
๐ LOWER END OF FEMUR is MORE COMMONLY affected. Therefore,
๐ The final diagnosis is OSTEOSARCOMA and
๐ They are associated with-
โ
Germline mutations
in RB gene
โ
p53 mutation
โ
INACTIVATION of
INK4a gene
โ
MDM2 and CDK4
OVEREXPRESSION
๐ The answer is 3) MDM2 and CDK4 overexpression
๐ Mutations in IDH1 and IDH2 genes are generally associated with ENCHONDROMAS
๐ Mutations in EXT1 or EXT2 genes are generally associated with OSTEOCHONDROMA
