Clinical Pathology - Quiz Section Solution with Explanation- Quiz 3

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Clinical Pathology - Quiz Section Solution with Explanation- Quiz 3

This is a unique clinical case series based quiz run by Dr Shagun Mehta ( MD , Path )- Creator of Pathology Bytes

Approach to this case will be -
📌 This histological picture shows POPCORN CELLS / LH (LYMPHOCYTE-HISTIOCYTE RICH VARIANT OF REED STERNBERG CELLS) cells and

📌 Popcorn cells are seen in Non-classical Hodgkin’s lymphoma / NLPHL(Nodular lymphocyte predominant Hodgkin’s lymphoma) and

📌 The differentiation of classical Hodgkin’s and non classical Hodgkin’s lymphoma is based on IMMUNOPHENOTYPING OF RS CELLS and

📌 Popcorn cells seen in NLPHL are POSITIVE for -
❇️ CD 20
❇️ CD 45
❇️ bcl 6

And NEGATIVE for -
🔴 CD 15
🔴 CD 30

🎉 The answer is 3) bcl-6

Popcorn cells in a case of NLPHL
Popcorn cells in a case of NLPHL

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