Approach to this case will be -
📌 This histological picture shows POPCORN CELLS / LH (LYMPHOCYTE-HISTIOCYTE RICH VARIANT OF REED STERNBERG CELLS) cells and
📌 Popcorn cells are seen in Non-classical Hodgkin’s lymphoma / NLPHL(Nodular lymphocyte predominant Hodgkin’s lymphoma) and
📌 The differentiation of classical Hodgkin’s and non classical Hodgkin’s lymphoma is based on IMMUNOPHENOTYPING OF RS CELLS and
📌 Popcorn cells seen in NLPHL are POSITIVE for -
❇️ CD 20
❇️ CD 45
❇️ bcl 6
And NEGATIVE for -
🔴 CD 15
🔴 CD 30
🎉 The answer is 3) bcl-6
